Structural analysis of a mouse mammary tumor virus superantigen.

Structural analysis of a mouse mammary tumor virus superantigen

It has recently been shown that the minor lymphocyte stimulating-like products expressed by some mice are actually encoded by open reading frames in the 3' long terminal repeats of mouse mammary tumor viruses. These products act as viral superantigens (vSAGs). That is, they stimulate most T cells bearing particular V beta s almost regardless of the rest of the variable components of the T cell ...

Paracrine Transfer of Mouse Mammary Tumor Virus Superantigen

Transfer of vSAG7, the endogenous superantigen encoded in the Mtv7 locus, from MHC class II to MHC class II+ cells has been suggested to occur both in vivo and in vitro. This transfer usually leads to the activation and deletion of T cells expressing responsive V beta s. However, there is no direct molecular evidence for such a transfer. We have developed an in vitro system which confirms this ...

Tumor Virus Superantigen Transcriptional Activation of Mammary Chromatin Structural Change in the Role of Ikaros, Demethylation, and Transcripts in Lymphomas of SJL/J Mice: Mammary Tumor Virus Superantigen Transcriptional Activator Initiated env Regulation of Mouse Mammary Tumor Virus

Virus Superantigen Increases Tumor Resistance Loss of Endogenous Mouse Mammary Tumor

A mouse mammary tumor virus-like long terminal repeat superantigen in human breast cancer.

We previously reported a 660-bp mouse mammary tumor virus (MMTV)-like env gene sequence in approximately 38% of human breast cancer DNA, but not in normal breasts or other tumors. This MMTV-like env gene sequence was expressed in 66% of the env gene-positive human breast cancers. An entire proviral structure was identified in human breast cancer DNA with high homology to MMTV and low homology t...